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DAA
       
The Distinguished Alumnus Award (DAA) is the highest award given by the Indian Institute of Technology Kanpur to its alumni in recognition of their achievements of exceptional merit.
 
Daa Profile-Arun Kumar Ghosh ( MSC2/CHM/81 )

Professor Arun K. Ghosh was a "National Science Talent Scholar", and earned a B. Sc. from Presidency college Calcutta. After completing his M. Sc. from IIT Kanpur in 1981, Professor Ghosh earned his Ph.D. degree in organic chemistry at the University of Pittsburgh followed by a postdoctoral fellowship at Harvard University with Nobel laurette E. J. Corey. He began his academic career at the University of Illinois at Chicago, where he rose to the rank of professor. In 2005, he moved to his current position of Ian P. Rothwell Distinguished Professor at Purdue University. Prof. Ghosh is the discoverer of an AIDS drug, which is named after him, Darunavir. Darunavir was approved by the US FDA on June 23, 2006. Darunavir is a second-generation protease inhibitor (PIs), designed specifically to overcome problems with the older agents in this class, such as Indinavir. Darunavir received much attention at the time of its release, as it represents an important treatment option for patients with drug-resistant HIV. Professor Ghosh’s scientific achievements have been well acknowledged by the scientific community in USA and he is the recipient of two coveted awards administered by the American Chemical Society. These awards are: The inaugural “Robert M. Scarborough Award for Excellence in medicinal Chemistry” (2008), and “The A. C. Cope Scholar Award” (2010). More recently, Dr. Ghosh has made seminal contributions to the structure-based design of CTS-21166, a compound in clinical development for the treatment of Alzheimer ’s disease. CTS-21166, is currently in phase-II trials. This drug is being developed by the pharmaceutical company, Comentis, which was co-founded by Arun Ghosh and is funded by a Japanese company, Astellas Pharmaceuticals, Inc: Besides the discovery of these two drugs, Professor Ghosh’s group has also synthesized various complex natural products, which incorporate multiple chiral centers and hence are quite challenging synthetically. The Ghosh group has also been the first to synthesize a few of these formidable natural products and has also been involved in the discovery of asymmetric synthetic methodology which is the Holy Grail for synthetic chemists. The Robert M. Scarborough Memorial Award endowed by Portola Pharmaceuticals, and conferred by the Division of Medicinal Chemistry of the American Chemical Society recognizes scientists under the age of 50 at the time of nomination. The awardee must have documented success in the discovery of pharmaceutical entities and/or a substantial body of significant research contributions in medicinal chemistry. Candidates should have a significant record of productivity as measured by the number and quality of scientific publications and issued patents. Nominees are expected to have demonstrated creativity and insight in medicinal chemistry and/or biology and emply pragmatic, empirical problem solving skills. He is conferred with the Distinguished Alumnus Award of the Indian Institute of Technology Kanpur for his outstanding contributions academic achievements in the field of discovery of drugs for AIDS.

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